Biosynthesis of metallic silver and copper nanoparticles, characterization, and their multidimensional biological applications

Nanotechnology is a novel interdisciplinary science serving as a nexus between the basic sciences. As multi-drug resistance in pathogens has rendered antibiotics ineffective, nanoparticles are the next frontier. Silver and Copper nanoparticles have been found to have applications in various applications, including those for antifungal, anti-inflammatory, antibacterial, antiviral, and bio-catalytic activity, as well as anticancer agents and medicines. materials for electrical batteries, optical receptors, catalysis in chemical reactions, biolabeling agents, sensors, bioactive materials, and antimicrobial agents in the biomedical fields.  including medical, agricultural, and environmental sectors, as bioactive and biocatalytic agents. Due to their enhanced responsiveness to environmentally friendly technology for quantifiable synthesis, several developed nations have seen significant growth in the biosynthesis of these metallic nanoparticles. The biological method, however, is the approach to preparation that is most in demand since it is quicker, safer, less expensive, and more environmentally friendly than other techniques. Recent reports indicate that fungi and bacteria are more susceptible to metallic nanoparticles. In our laboratory, metallic silver nanoparticles (BioAgNPs) were synthesized through an eco-friendly approach with the cell-free filtrate of microbial sources. viz fungi (Aspergillus niger, Aspergillus flavas, and Agaricus bisphoris ) Actinobacteria (Actinomycetes ), and the plant parts (leaves, flowers, stems,) extracts as source, various plants, Piper bettle, Ocimum leaves, Azadirita indica, Ficus religiosa, and Zuzuphus similarly copper nanoparticles also synthesized through using plant material. The synthesized AgNPs and CuNPs were characterized by UV-visible spectroscopy, FTIR, SEM, and DLS analysis to further examine the morphological properties, including size, shape, and stability. The probable mechanism for the extracellular biosynthesis of silver nanoparticles was explained.  The synthesized silver and copper nanoparticles showed good antibacterial, antifungal, and antioxidant properties. Based on their multiple biological properties, AgNPs and CUNPs could be used as potent bioactive agents for modern medical and Agricultural sectors.

Dr. Narasimha Golla is working as a Professor and Dean (R&D) at Sri Venkateswara University, India. His research  area, Applied Microbiology and Nanotechnology aspects, Bioactive compounds, metallic and nonmetallic nanoparticles, characterization, and their biological applications as potential antimicrobial, anticancer, antiviral, and biocatalytic agents in modern medicine and bioremediation. Dr. Narasimha has published more than 160 research papers in reputed National and International journals. He attended National and International conferences, and seminars, presented documents, and served as an expert member of scientific programs. He handled major research projects sponsored by the Department of Biotechnology, the University Grants Commission, and the Board of Nuclear Sciences, India, He published books and book chapters in internationally reputed journals. He served as editor, editorial, and advisory board member for National and International peer-reviewed journals.  Prof. Narasimha is a member of the American Society (AMN), the Indian Science Congress (ISCA), the Asian Council of Science Editors (ACSE), and the Andhra Pradesh Academy of Science. (APAS) Member and President of the Microbiology Society of India (AP -MBSI). He received National and International Reorganizations and awards like Highly Cited Researcher, (Elsevier, Netherlands) BRAVe Faculty, (Athens, Greece), Young Faculty (MG. University. India) Research Excellence Award (Indo-American summit) IconsSWM-CE Excellence Award (IconSWM-CE-2022) Senior Scientist Award (ABAP-2023), name indexed in A.D, World Scientific Index-2024, Dr. Narasimha looks forward to developing his eminence in modern science and technology.